Two sample MR report
HLA-A_Dendritic Cell (DC) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | 0.3549241 | 0.4822200 | 0.4827380 |
| Weighted median | 10 | -0.1180830 | 0.0332431 | 0.0003822 |
| Inverse variance weighted | 10 | -0.1094092 | 0.0273886 | 0.0000648 |
| Simple mode | 10 | -0.1239565 | 0.0561459 | 0.0546449 |
| Weighted mode | 10 | -0.1233552 | 0.0546384 | 0.0503686 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.186055 | 8 | 0.9221446 |
| Inverse variance weighted | 4.116247 | 9 | 0.9035961 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1722847 | 0.1786324 | 0.3630579 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001512 | 0 | TRUE | 0.2451048 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
